Mycobacterium leprae Hsp65 administration reduces the lifespan of aged high antibody producer mice
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چکیده
منابع مشابه
A Mycobacterium leprae Hsp65 Mutant as a Candidate for Mitigating Lupus Aggravation in Mice
Hsp60 is an abundant and highly conserved family of intracellular molecules. Increased levels of this family of proteins have been observed in the extracellular compartment in chronic inflammation. Administration of M. leprae Hsp65 [WT] in [NZBxNZW]F(1) mice accelerates the Systemic Lupus Erythematosus [SLE] progression whereas the point mutated K(409)A Hsp65 protein delays the disease. Here, t...
متن کاملTemperature optimum of Mycobacterium leprae in mice.
Shepard, Charles C. (Communicable Disease Center, Atlanta, Ga.). Temperature optimum of Mycobacterium leprae in mice. J. Bacteriol. 90:1271-1275. 1965.-Mycobacterium leprae multiplied most rapidly in foot pads of mice kept at an air temperature of 20 C. At air temperatures of 15 and 25 C, bacillary multiplication was slightly slower; at 10 and 30 C, distinctly slower; and at 4 and 35 C, no baci...
متن کاملAdministration of M. leprae Hsp65 Interferes with the Murine Lupus Progression
The heat shock protein [Hsp] family guides several steps during protein synthesis, are abundant in prokaryotic and eukaryotic cells, and are highly conserved during evolution. The Hsp60 family is involved in assembly and transport of proteins, and is expressed at very high levels during autoimmunity or autoinflammatory phenomena. Here, the pathophysiological role of the wild type [WT] and the p...
متن کاملAirborne infection with Mycobacterium leprae in mice.
Although the portal of entry and mode of spread of M. leprae in human leprosy are still uncertain, it is widely held that direct person-to-person skin contact is important. This assumption has ignored the fact that patients with highly bacilliferous leprosy have nasal as well as dermal infection and that, since M. leprae is shed predominantly from the nose, leprosy might be an airborne infectio...
متن کاملAdministration of Mycobacterium leprae rHsp65 Aggravates Experimental Autoimmune Uveitis in Mice
The 60 kDa heat shock protein family, Hsp60, constitutes an abundant and highly conserved class of molecules that are highly expressed in chronic-inflammatory and autoimmune processes. Experimental autoimmune uveitis [EAU] is a T cell mediated intraocular inflammatory disease that resembles human uveitis. Mycobacterial and homologous Hsp60 peptides induces uveitis in rats, however their partici...
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ژورنال
عنوان ژورنال: Immunity & Ageing
سال: 2014
ISSN: 1742-4933
DOI: 10.1186/1742-4933-11-6